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Importance of foreign languages for accepting to work position
Křenek, Lukáš ; Konečná,, Zdeňka (referee) ; Pokorný, Jiří (advisor)
This work shows us a fact, how knowledge of foreign languages is important for entrance to enterprise, witch we’re trying to reach with studying high school. Bachelor’s thesis describes memory, learning, forgetting and also methods, witch confirm prime thesis. One of these methods is submission of questionnaires to enterprises to find out requirements of employers and another are language tests. Tests will be written by students of first and third grades and tell language level. The last object of bachelor’s thesis is finding possibilities of keeping foreign language literacy.
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Mechanisms of iron-sulfur cluster biogenesis in eukaryotes
Temešinko, Tomáš ; Doležal, Pavel (advisor) ; Malych, Ronald (referee)
Many essential cellular proteins use iron-sulfur (Fe-S) clusters as cofactors. These proteins often serve as enzymes, components of the electron-transport chain or as intracellular sensors. Prior to the use of the cluster in a protein, it needs to be formed or created de novo. In total, four different mechanisms of Fe-S cluster biogenesis can be used by the eukaryotic cell - ISC, CIA, SUF and NIF. All of these pathways include a specific targeting system for delivering the cluster to its acceptor protein. Errors in biosynthesis ofFe-Sclustersaremostlylethalandcanleadtofailureindevelopmentofmulticellularorganisms.Despite this a better characterization of these mechanisms is needed as research is currently still in progress. This bachelor's thesis provides current information regarding the mechanisms of Fe-S clusters biogenesis in eukaryotes acquired mostly from mammalian cells, including humans, and from well-known model organisms such as Saccharomyces cerevisiae, Arabidopsis thaliana, and parasitic protist Giardia intestinalis.
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Iron-sulphur cluster synthesis in anaerobic protists
Zelená, Marie ; Hampl, Vladimír (advisor) ; Mach, Jan (referee)
Iron-sulpur clusters are small ubiquitous cofactors of proteins present in all cells. These proteins participate in many important processes such as gene expression or respiratory chain. In vivo synthesis of iron-sulphur clusters requires complex biosynthetic pathways. In eukaryotic cells these pathways are localized inside mitochondria and plastids and in the cytosol. Cytosolic synthesis depends on a product of the mitochondrial pathway. Mitochondria of anaerobic protists in most cases went through reductive evolution, which is associated with the reduction of mitochondrial iron-sulphur cluster biosynthetic pathway. In many cases, these organisms acquired alternative pathways via lateral gene transfer, which act either as a complement to the mitochondrial pathway, or as its complete functional substitution. Replacement of the mitochondrial pathway might have been a key event for secondary loss of mitochondria. Key words: Iron-sulphur clusters, anaerobic protists, ISC, CIA, SUF, mitochondrion
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Export of biomolecules from mitochondria
Pelc, Josef ; Doležal, Pavel (advisor) ; Kovalčíková, Jana (referee)
Mitochondrion is cellular organelle evolved from the endosymbiotic bacteria. Because of its bacterial origin mitochondrion has a number of unique properties and metabolic pathways. Mitochondria or its reduced forms are present in all eukaryotic organisms except a single exception. During the course of evolution most of mitochondrial DNA was transferred to the nucleus. Despite this, mitochondria still encode several proteins that are part of the electron transport chain and the ATP synthase. These proteins are transported from the mitochondrial matrix into the inner mitochondrial membrane. Misfolded proteins of the inner membrane are degraded by mitochondrial proteases, which leads to the release of generated peptides. Fe-S clusters are assembled in the mitochondrial matrix. Still unknown molecule, which is product of ISC pathway is transported into cytosol and participates in the assembly of cytosolic and nuclear iron-sulfur proteins. Other transport pathway ensures the exchange of lipids between the endoplasmic reticulum and mitochondria. Both mitochondrial membranes have different lipid composition. To maintain their properties specific lipid transport is required between the two mitochondrial membranes. This transport pathway is also used for the lipid synthesis in the inner mitochondrial membrane.
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Importance of foreign languages for accepting to work position
Křenek, Lukáš ; Konečná,, Zdeňka (referee) ; Pokorný, Jiří (advisor)
This work shows us a fact, how knowledge of foreign languages is important for entrance to enterprise, witch we’re trying to reach with studying high school. Bachelor’s thesis describes memory, learning, forgetting and also methods, witch confirm prime thesis. One of these methods is submission of questionnaires to enterprises to find out requirements of employers and another are language tests. Tests will be written by students of first and third grades and tell language level. The last object of bachelor’s thesis is finding possibilities of keeping foreign language literacy.
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Comparison of consumer price indices in the Czech Republic and the EU
Hanzal, Vít ; Fischer, Jakub (advisor) ; Trexler, Jiří (referee)
The aim of the bachelor thesis is to theoretically explain the concept of price statistic and his subcategories such as national (CPI) and Harmonised (HICP) Index of Consumer Prices with help from Czech statistical office and suitable literature. During the explanation of the concept of CPI is also enlightened classification of COICOP and meaning of the weight system. The prediction of the progress of weights of categories COICOP_1 and COICOP_4, is created in practical part. Moreover the hypothesis was created whether the weights of categories COICOP_1 and COICOP_4 are closing to average values of the EU. This prediction is achieved by statistical methods such as trend functions and exponencional smoothing. Slight increase of values is predicted for the weights of category COICOP_1, instead of category COICOP_4, where was predicted constant progress of the weights. In last chapter we set up a hypothesis, whether the progress of values HICP is closing to the values of EU. Also it was necessary to prove seasonality and then subsequently create a prediction of value progress, which was acomplished by exponential smoothing. The results verified the hypothesis, that the progress of HICP in CR gradually descents and that it closes to the values HICP of the EU.
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